What the Professionals Say About Nitric Oxide

 It helps maintain blood pressure by dilating blood vessels, helps kill foreign invaders in the immune response, is a mediator of penile erection, and is probably a major biochemical component of long-term memory… [these are] just a few of it benefits…

-The editors of the highly prestigious journal Science, after voting nitric oxide the 1992 molecule of the year.

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“One of the most exciting new findings in cardiovascular medicine involves the molecule nitric oxide or NO. We now know that our bodies produce nitric oxide in the endothelium, a delicate tissue that is the inner lining of the blood vessel. The endothelium is so significant to blood vessel health that I predict that in the next few years the health of your endothelium will become as important as cholesterol to your doctor.”

The Cardiovascular Cure

John P. Cooke M.D., Ph. D.

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“Surprises at the cellular level turn up all the time. In Nature, nitric oxide is a formidable toxin and a common component of air pollution. So scientist were naturally a little surprised when in the mid-1980s, they found it being produced in a curiously devoted manner in human cells. Its purpose was at first a mystery, but then scientists began to find it all over the place-controlling the flow of blood and energy levels of cells, attacking cancers and other pathogens, regulating the sense of smell, even assisting in penile erections. It also explained why nitroglycerine, the well known explosive, soothed the heart pain known as angina. (It is converted into nitric oxide in the blood stream, relaxing the muscle linings of vessels, allowing blood to flow more freely.)  In barely the space of a decade this one gassy substance went from extraneous toxin to ubiquitous elixir”. 

 

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“I have been immersed in biological research for more than half a century, and in 1982, received the Nobel Prize for my discovery of a prostaglandin that was called prostacylin…..

Over the last 50 years biologists have discovered many different mediators or chemical messengers, which transmit signals from one cell to another……

Less than 15 years ago a different and very potent mediator of blood vessel relaxation and inhibition of platelet clumping was identified as Nitric Oxide (NO). It is the simplest messenger of them all……

There are special enzymes that generate NO from Arginine and we now know it has important functions in the brain, the immune system and vasculature…..”

 

Sir John Vane, D.Sc. F.R.S.

Nobel Laureate 1982

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“Arginine-derived nitric oxide, or ADNO, is a multi faceted molecular marvel, one made all the more amazing by the fact that researchers only recently discovered that it even exists inside human tissues.”

 

The Arginine Solution

Robert Fried, Ph., D. Woodson C. Merrell, M.D.      

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Studies Have Shown that Nitric Oxide is Key to the Body's Overall Health and Performance

Scientific research from around the world has demonstrated that Nitric Oxide is one of the most significant molecules in the body and is crucial to health and well-being. 

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What is Nitric Oxide?

•    Nitric Oxide or NO, a highly unstable gas, occurs when Nitrogen (symbol N) and Oxygen (symbol O) join together.

What Isn’t Nitric Oxide (NO)?

•    Nitrous Oxide (laughing gas) is the chemical compound N2O. It is a colorless, almost odorless gas, first discovered in 1793 by the English scientist Joseph Priestley. It is a much more stable gas than NO.

•    Nitrogen dioxide (NO2), as a reddish-brown gas with a characteristic sharp, biting odor. NO2 is one of the most prominent air pollutants and a poison by inhalation.

NO vs ADNO

•    NO therapy – medicine often sees NO therapy as the administration of actual Nitric Oxide gas (for example: as administered to premature infants with undeveloped lungs).

•    As NO can convert to poisonous NO2 when exposed to oxygen, direct NO can be toxic and deadly.

ADNO therapy

•    Arginine Derived Nitric Oxide uses Nitric Oxide pre-cursers to allow the body to produce it’s own Nitric Oxide via Nitric Oxide Synthases which convert Arginine to Nitric Oxide. 

Nitric Oxide Synthases

•    At this time three distinct Nitric Oxide Synthases (NOS) have been discovered falling into two categories:

•    1) constitutive – endothelial and neuronal NOS. These synthases are calcium dependent and can be drive by hormones in the body such as estrogen and progesterone (i.e. pregnancy).

•    2) inducible – inducible NOS. This synthase is not calcium dependent and is driven when the immune system is attacked such as in the case of an infection or injury.

ADNO

•    Arginine-derived nitric oxide, or ADNO, is a multifaceted molecular marvel

•    one made all the more amazing by the fact that researchers only so recently discovered that it even exists inside human tissues (1998).

The 3 known Nitric Oxide Synthases

•    Endothelial – known as eNOS. This synthase signals the endothelial tissue of blood vessels to relax and dilate.

•    Neuronal – known as nNOS. This synthase is a neurotransmitter and communicator between brain cells and can also signal eNOS.

•    Inducible – known as iNOS. This synthase is our immune system synthase, capable of programming apoptosis in cancer cells.

NO in the news

•    1992 – NO is named “Molecule of the Year”

•    1998 – The Nobel Prize in Science is awarded to three American Scientists (Ignarro) for determining that Nitric Oxide, signaling in blood vessels, plays a key role in cardiovascular regulation.

The many jobs ADNO has now been shown to perform inside the body:

•    Relaxes arteries, thereby helping to maintain normal blood pressure, which would otherwise skyrocket when ADNO is in short supply.

•    Helps keep open the coronary arteries that supply blood to the heart, preventing angina pain.

•    potent free-radical scavenger that helps to both lower serum cholesterol and prevent the “bad” LDL cholesterol from oxidizing and becoming even worse.

•    Powerful anticoagulant, or blood thinner, that helps prevent blood platelets from clumping together into the clots that can cause heart attack and stroke.

•    Enhances blood flow to the penis, helping to boost erections (think Viagra).

•    Serves as a critical “bullet” by different immune-system cells that use it to kill foreign bacteria and viruses and even shrink or destroy some cancerous tumors.

From “The Arginine Solution” 1999 by Robert Fried, Ph.D., Woodson C. Merrell, M.D., and James Thornton, MD.

The many jobs ADNO has now been shown to perform inside the body:

•    Encodes long-term memory & ensure blood flow to brain cells (neuronal).

•    Functions as a “messenger molecule” allowing nerve cells in the body and the brain to communicate with each other (neuronal).

•    May reduce pregnancy-related hypertension, potentially life-threatening to mother & baby (endothelial).

•    May help regulate insulin secretion by the pancreas, thereby reducing diabetes risk.

•    Helps control lung airways, allowing easier breathing and avoidance of lung disorders.

•    Relaxes “hypertonic” sphincter muscles, preventing and healing hemorrhoids and anal fissures.

•    Stimulates body into releasing the all-important human growth hormone (HGH), a key to longevity as well as improvement in body composition by boosting lean muscle mass and bone density while decreasing fat tissue.

From “The Arginine Solution” 1999 by Robert Fried, Ph.D., Woodson C. Merrell, M.D., and James Thornton, MD.

Nitric Oxide: Pioneering PC treatment?

Researchers from the University of Utah and the National Cancer Institute developed an experimental drug that reacts with a substance inside cancer cells, releasing nitric oxide to kill the cells or slow their growth without harming healthy cells.

Tests showed the drug, called JS-K, induced the cell-suicide process in acute myeloid leukemia (AML) cells grown in culture and inhibited their growth in mice. In other tests on cell cultures, the drug also inhibited growth of AML cells and - to a lesser extent - prostate, colon and breast cancer cells. It also inhibited growth of prostate cancer cells in mice.

"If all goes well, this would be the first cancer chemotherapeutic agent based on selective delivery of nitric oxide to tumor cells and therefore would constitute a novel class of cancer drugs. It looks promising in cell culture and mice, but much work needs to be done before we know if it can be used in humans for the treatment of cancer.“ - Paul Shami, MD, associate professor of medical oncology at the University of Utah School of Medicine.

      Molecular Cancer Therapeutics, April 2003.