PLE

Protein losing enteropathy is a disease affecting the gastro intestinal system resulting in protein loss when the epithelial cell barrier is lost due to mucosal ulceration, or when interstitial edema disrupts the tight junctions between epithelial cells. Protein-losing enteropathy has most commonly been associated with mucosal absorptive defects such as granulomatous enteritis, eosinophilic gastroenteritis, gastrointestinal neoplasia (lymphosarcoma, and squamous cell carcinoma), intestinal parasitism, acute salmonellosis, congestive heart failure and NSAID toxicity.