Bute Toxicity

Experimentally induced Bute toxicosis in ponies produces ulcerations in the mucosa of the tongue, gingiva, hard palate, stomach, small intestine and the colon. Gastric ulceration induced by NSAIDs involves increased gastric mucosal permeability to hydrogen ions, inhibition of mucus synthesis, and decreased gastric mucosal blood flow. There is growing evidence in humans that NSAID toxicity (example: ibuprofen) increases permeability of the small and large intestinal mucosa by damaging the intercellular junctions.